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教授

徐向群

发表于:2018-01-24  浏览人数:

http://sky.zstu.edu.cn/ewebeditor/uploadfile/20151123091631333.jpg

  徐向群

         博士、教授、硕士生导师

         浙江省新世纪151人才第三层次

         出生日期:1965.6

         办公室:6-445

         邮箱:xuxiangqun@zstu.edu.cn

 

学历

博士:生物医学工程, 英国University of Keele, 1999.10-2003.3

硕士:生物化学, 浙江医科大学, 1996.9-1997.12

学士:生物化学,厦门大学, 1981.9-1985.7

工作经历

2003.9-至今 浙江理工大学生命科学学院 教授

2002.3-2013.8 英国Cranfield University 博士后研究助理

1985.8-1999.9 中国农业科学院茶叶研究所 研实、助研

2007.6-12, 2009.7-10, 2012.7-10, 2015.6-9 美国加州大学尔湾分校访问学者、项目科学家

1997.9-1998.7 英国University of Surrey 访问学者

主要研究方向

  • 药食用真菌生物合成活性物质的生物技术、代谢调控和药用活性

  • 木质纤维素生物降解及饲料、平台化学品、活性物质转化

  • 白腐真菌木质纤维素降解酶产生的代谢调控和基因表达

  • 药食用真菌活性成分生物合成酶的代谢调控和基因表达

  • 功能性光相干断层成像技术及医学应用

主持科研项目

1、      国家自然科学基金光相干层析成像研究血液凝固过程中的光学性质动态变化及特征参数81171378),2012-201558万。

2、      国家自然科学基金面向无创在体检测红细胞聚集性的光相干多普勒方差成像新方法30870675),2009-201133万。

3、      国家自然科学基金用物化方法提高生物组织相干光断层成像深度的研究30470426),2005-2007, 26万。

4、      浙江省自然科学基金项目不同类型木质纤维素的液体发酵桦褐孔菌降解模式、产酶规律和促进作用研究LY16B020013),2016-201810万。

5、      浙江省自然科学基金项目辅助手段提高皮肤光穿透深度的作用机理X206958),2008-20103 万。

6、      浙江省科技计划项目药用桦褐孔菌活性多糖的液体深层发酵制备研究2012C23075),2012-201415万。

7、      浙江省科技计划重点国际合作项目蔬菜病虫害防治新型多功能生物农药研制2007C24016),2007-200920万。

8、      浙江省教育厅留学回国专项渗透促进剂提高皮肤光透明效率研究2005-20073

9、      教育部留学回国人员科研启动基金提高生物组织中光穿透深度的化学及物理方法研究2005-20073万。

10、    人事部留学回国人员科研活动择优资助项目改善相干光断层成像对生物组织的探测深度和成像对比度的技术研究20050.8万。

获奖

 

11992年国家科技进步二等奖,茶叶天然抗氧化剂提取及其应用,(5/9)。

21990年农业部科技进步一等奖,茶叶天然抗氧化剂提取及其应用,(5/9)。

31999年农业部科技进步三等奖,茶叶功能食品的开发利用(第7/15

授权专利

1、徐向群:液体深层发酵生产桦褐孔菌免疫增强活性物质的工艺(ZL 201310055029.5

2、徐向群:桦褐孔菌多糖在凡纳滨对虾饲料中的应用(ZL 201310163787.9

代表性论文(*表示通讯作者)

1.            Xu X.*, Shen M., Quan L. (2015) Stimulatory agents simultaneously improving the production and antioxidant activity of polyphenols from Inonotus obliquus by submerged fermentation.  Appl. Biochem. Biotec-h., 176(5):1237-1250

 

2.            Xu X.*, Quan L., Shen M.  (2015) Effect of chemicals on production, composition and antioxidant activity of polys-accharides of Inonotus obliquus. Int. J Biol. Macromol., 77, 143-150.

 

3.            Xu X.*, Hu Y., Zhu L. (2014) The capability of Inonotus obliquus for lignocellulosic biomass degradation in peanut shell and for simultaneous production of bioactive polysaccharides and polyphenols in submerge-d fermentation. J Taiwan Inst Chem Eng., 45(6):2851-2858.

4.            Xu X.*, Hu Y., Quan L. (2014) Production of bioactive polysaccharides by Inonotus obliquus under su-bmerged fermentation supplemented with lignocellulosic biomass and their antioxidant activity. Bioprocess Bios-yst Eng. 12(37), 2483-2492.

5.            Xu X.*, Li J, Hu Y. (2014) Polysaccharides from Inonotus obliquus sclerotia and cultured mycelia stimulate cytokine production of human peripheral blood mononuclear cells in vitro and their chemical characterizationInt Immunopharmacol., 21(2), 269-278.

 

6.            刘小玲,徐向群,黄燕华,曹俊明,王国霞,莫文艳,吴春玉,付晶晶. (2013) 桦褐孔菌多糖对凡纳滨对虾生长和血清免疫相关酶活性的影响. 水产科学, 33(4), 201-207.

 

7.            Zhu L., Xu X.* (2013) Stimulatory effect of different lignocellulosic materials for phenolic compound production and antioxidant activity from Inonotus obliquus in submerged fermentation. Appl. Biochem. Biotec-h., 169, 2138-2152.

 

8.            Xiang Y., Xu X.* and Li J. (2012) Chemical properties and antioxidant activity of exopolysaccharides fractions from mycelial culture of Inonotus obliquus in a ground corn stover medium. Food Chemistry, 134: 1899–1905.

 

9.            Xu. X.*, Wu Y. and Chen H. (2011) Comparative antioxidative characteristics of polysaccharides from natural scleraotia and cultured mycelias in submerged fermentation of Inonotus obliquus. Food Chemistry 127, 74-79.

 

10.            Chen H. Yan M. and Xu X.* (2011) Enhancement of exo-polysaccharide production and antioxidant activeity in submerged cultures of Inonotus obliquus by lingocellulose decomposition. J. Ind Microbiol Biotechn-ol. 38, 291-298.

 

11.            Xu. X.* and Zhu J. (2011) Enhanced phenolic antioxidants production in submerged cultures of Inonotus obliquus in a ground corn stover medium. Biochem Eng J. 58-59, 103-109.

 

12.            Xu. X.*,Yu Y. and Shi Y. (2011) Evaluation of inert and organic carriers for Verticilium lecanii spor-e production in solid-state fermentation. Biotechnol Lett. 33:763-768.

 

13.            Chen, H., Xu, X.* and Zhu, Y. (2010) Optimization of hydroxyl radical scavenging activity of exo-polysaccharides from Inonotus obliquus in submerged fermentation using response surface methodology. J. Micr-obiol. Biotechnol. 20(4), 835-843

 

14.            Shi Y., Xu X.* and Zhu Y. (2009) Optimization of Verticillium lecanni spore production in solid-state fe-rmentation on sugarcane bagasse. Applied Microbiology & Biotechnology 82(5):921-927.

 

15.            Xu X.*, Shi Y., and Zhu Y. (2008) Verticillium lecanii spore production in solid-state fermentation usi-ng inert carrier. Journal of Biotechnology 136S, S474.

 

16.            Xu X.*, Mo Y., Yan M. and Zhu Y. (2007) Analysis of characteristic aroma of fungal fermented Fuzh-uan brick-tea with Gas Chromatography-Mass Spectrophotometer. J. Sci Food Agric. 87(8), 1502-1504.

 

17.            Xu X.*, Yan M. and Zhu Y. (2005) Influence of fungal fermentation on the development of volatile co-mpounds in the Puer tea manufacturing process. Engineering in Life Science. 5(4) 364-368.

 

18.            Mo H., Xu X., Yan M., Zhu Y. (2005) Microbiological analysis and antibacterial activity of the indigeno-us fermented Puer tea. Agro Food Industry Hi Tech. 16(6), 16-18.

 

19.            Xu X.*, Zhu J. and Chen Z. A new approach for assessment of blood coagulation using shear wave o-ptical coherence elastography with Doppler variance method. Submitted.

 

20.            Xu X.* and Teng X. (2015) Assessment of flowing blood coagulation under impact of fibrinogen con-centration using optical coherence tomography. IEEE selected topics in Quantum electronics, 22(3), 1-7.

 

21.            Xu X.* and Teng X. (2015) Effect of fibrinogen on blood coagulation detected by optical coherence t-omography. Phys. Med. Biol. 60, 4185-4195.

 

22.            Xu X.*, Geng J. and Teng X. (2014) Monitoring the blood coagulation process under various flow con-ditions with optical coherence tomography. J. Biomed. Opt., 19(4), 046021-1-7.

 

23.            Xu X.*, Geng J. Liu G. and Chen Z. (2013) Evaluation of optical coherence tomography for the meas-urement of the effects of activators and anticoagulants on the blood coagulation in vitro. IEEE Trans. Biome-d. Eng., 20(4), 2100-2106.

 

24.            Fu F., Xu X.* and Geng J. (2012) Characterization of flowing blood optical property under various fibr-inogen levels using optical coherence tomography. IEEE Transaction Biomedical Engineering, 59(9), 2613-2618.

 

25.            Xu X.*, Lin J. and Fu F. (2011) Optical coherence tomography to investigate optical properties of blo-od during coagulation. Journal of Biomedical Optics 16(9), 096002-1-7

 

26.            Xu X.*, Yu L. and Chen Z. (2010) Velocity variation assessment of red blood cell aggregation with spectral domain Doppler optical coherence tomography. Annals of Biomedical Engineering 38(10), 3210-3217.

 

27.            Xu X.*, Ahn Y.-C. and Chen Z. (2009) Feasibility of Doppler variance imaging for red blood cell aggr-egation characterization,” J. Biomed. Opt, vol. 14(6), 1-3.

 

28.            Xu X.*, Zhu Q. and Sun C. (2009) Assessment of the effects of ultrasound-mediated alcohols on skin optical clearing. Journal of Biomedical Optics 14(3), 034042-1-5.

 

29.            Xu X.*, Zhu Q. and Sun C. (2008) Combined effect of ultrasound-SLS on skin optical clearing. IEEE Photonics Technology Letters 20(24), 2117-2119.

 

30.            Xu X.* and Zhu Q. (2008) Sonophoretic delivery for contrast and depth improvement in skin optical coherence tomography. IEEE Journal of selected topics in Quantum electronics 14(1), 56-61.

 

31.            Xu X.* and Zhu Q. (2008) Feasibility of sonophoretic delivery for effective skin optical clearing. IEEE Transactions on Biomedical Engineering. 55(4), 1432-1437.

 

32.            Xu X.*, Yu L. and Chen Z. (2008) Optical clearing of flowing blood using dextrans with spectral domain optical coherence tomography. Journal of Biomedical Optics. 13(2), 021107.(This article has been selected for the June 1, 2008 issue of the Virtual Journal of Biological Physics Research)

 

33.            Xu X.*, Yu L. and Chen Z. (2008) Effect of erythrocyte aggregation on hematocrit measurement using spectral domain optical coherence tomography. IEEE Transactions on Biomedical Engineering. 55(12) 2753-2758.

 

34.            Xu X.* and Zhu Q. (2007) Evaluation of skin optical clearing enhancement with azone as a penetration enhance azone. Opt. Commun. 279, 223-228.

 

35.            Xu X.* and Wu L. (2005) Influence of permeation characteristics of hyperosmotic agents on optical clearing of gastric tissue studied with near-infrared spectroscopy. Chinese J. Lasers 32(5), 717-722.

 

36.            Xu X. and Wang R.K. (2004) Synergistic effect of hyperosmotic agents on optical clearing of gastric t-issue studied with near infrared spectroscopy. Physics in Medicine & Biology 49, 457-468.

 

37.            Xu X. and Wang R.K. (2003) The role of water desorption on optical clearing of biotissue: studied wit-h near infrared reflectance spectroscopy. Medical Physics 30, 1246-1253.

 

38.            Xu X., Wang R.K. and Elder J.B. (2003) Optical clearing effect on gastric tissues immersed with bioc-ompatible chemical agents investigated by near infrared reflectance spectroscopy. J. Physics D: Appl. Physics 36, 1707-1713.

 

39.            Xu X., Wang R.K., Elder J.B. and Tuchin V.V. (2003) Effect of dextran-induced changes in refractiv-e index and aggregation on optical properties of whole blood. Physics in Medicine & Biology 48, 1205-1221.

 

40.            Xu X., Wang R.K. and El Haj A. (2003) Investigation of changes in optical attenuation of bone and ne-uronal cells in organ culture or 3 dimensional constructs in vitro with optical coherence tomography: relevance to cytochrome-oxidase monitoring. European biophysics Journal 32, 355-362.

 

41.          &nbs,p; Wang R.K., Xu X., He Y. and Elder J.B. (2003) Investigation of optical clearing of gastric tissue immer-sed with the hyperosmotic agents. IEEE selected topics in Quantum electronics 9, 234-242.

 

42.            Tuchin V.V., Xu X. and Wang R.K. (2002) Dynamic optical coherence tomography in studies of optica-l clearing, sedimentation, and aggregation of immersed blood. Applied Optics. 2002, 1 (1), 1-14.

 

43.            Wang R.K., Xu X., Tuchin V.V. and Elder J.B. (2001) Concurrent enhancement of imaging depth and c-ontrast for optical coherence tomography by hyperosmotic agents. Journal of Optical Society of America B. 18 (7), 948-953.