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李恭楚

发表于:2016-06-30  浏览人数:

电子版照片

李恭楚

别:男

出生年月:1973 4

称:副教授

细胞生物学

室: 6-215

话: 86843186

电子邮件:lgc@zstu.edu.cn

主要学习工作经历

1.纽约州立大学宾汉姆顿分校生物科学系博士

2.华东师范大学生物学系 学士、硕士

主要研究方向

1.凝集素基因在肿瘤基因治疗中的应用及分子机制研究

2.肿瘤免疫学

科研教学项目

主持的项目:

1.国家自然科学基金面上项目,“凝集素基因在溶瘤痘苗病毒为载体的癌症基因治疗中的应用及分子机制研究”(81572986)2016.01-2019.12

2.浙江省自然科学基金重点项目,“海洋凝集素基因在肿瘤基因治疗中的应用及作用机制研究”(LZ16D060002)2016.01-2019.12

3.国家自然科学基金青年项目,“通过急性髓性白血病干细胞表面CD123导入溶瘤腺病毒的实验研究” (30801379)2009.01-2011.12

作为课题设计者和主要完成人的项目:

1.国家自然科学基金青年项目,“掌叶半夏凝集素细胞内表达杀伤肺癌细胞的研究”(30800093)2009.01-2011.12

代表性论著( §:第一作者;*:通讯作者

G Li*, H Wu, L Cui, Y Gao, L Chen, X Li, T Liang, X Yang, J Cheng, J Luo. CD47-retargeted oncolytic adenovirus armed with melanoma differentiation-associated gene-7/interleukin-24 suppresses in vivo leukemia cell growth. Oncotarget 2015 (In press)

L Wu§, X Yang§, X Duan, L Cui, G Li*. Exogenous expression of marine lectins DlFBL and SpRBL induces cancer cell apoptosis possibly through PRMT5-E2F-1 pathway. Scientific Reports 4: 4505. 2014

G Li*, X Li, H Wu, X Yang, Y Zhang, L Chen, X Wu, L Cui, L Wu, J Luo, XY Liu. CD123 targeting oncolytic adenoviruses suppress acute myeloid leukemia cell proliferation in vitro and in vivo. Blood Cancer Journal 4: e194. 2014

X Yang§, L Wu§, X Duan, L Cui, J Luo, G Li*. Adenovirus carrying gene encoding Haliotis discus discus sialic acid binding lectin induces cancer cell apoptosis. Marine Drugs 12: 3994-4004. 2014

N Li§, G Dong§, S Wang, S Zhu, Y Shen, G Li*. Pinellia pedatisecta agglutinin-based lectin blot analysis distinguishes between glycosylation patterns in various cancer cell lines. Oncology Letters 8: 837-840. 2014

K Chen, X Yang, L Wu, M Yu, X Li, N Li, S Wang, G Li*. Pinellia pedatisecta agglutinin targets drug resistant K562/ADR leukemia cells through binding with sarcolemmal membrane associated protein and enhancing macrophage phagocytosis. PLoS ONE 8: e74363. 2013

Q Lu§, N Li§, J Luo, M Yu, Y Huang, X Wu, H Wu, XY Liu, G Li*. Pinellia pedatisecta agglutinin interacts with the methylosome and induces cancer cell death. Oncogenesis 1: e29. 2012

BJ Rafferty§, G Li§, DW McGee*. Activation of the α3 integrin affects TRAF6 function in the IL-1 signaling pathway of Caco-2 epithelial cells. Immunological Investigations 39: 1-15. 2010

GC Li§, N Li§, YH Zhang, X Li, YG Wang, XY Liu, WB Qian*, XC Liu*. Mannose-exposing myeloid leukemia cells detected by the sCAR-PPA fusion protein. International Journal of Hematology 89: 611-617. 2009

G Li, FD Lubin, DW McGee*. α3β1 integrin induced Suppression of the Caco-2 epithelial cell IL-1 signaling pathway leading to NF-κB activation. Cellular Immunology 231: 30-39. 2004