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韩兵男(特聘教授)

发表于:2016-06-30  浏览人数:


 

 

     

   

  姓名:韩兵男

  特聘教授

  研究领域:海洋生物资源利用

   E-mailhanbingnan@zstu.edu.cn

 

 

 

 

一、高等教育

 

 

2000/09 – 2005/06,美国俄勒冈州立大学(Oregon State University),药学院,海洋天然产物及药物化学,博士

导师:William H. Gerwick 教授

课题:海洋蓝藻的抗癌次生代谢物的化学研究

1996/10 –1999/12,   美国加州州立大学(California State University, Northridge),有机化学,硕士

1990/09 – 1994/06,杭州大学,生物化学与微生物学,本科

 

 

二、工作简历

 

2017/01至今,浙江理工大学生命科学学院,特聘教授

2013/032016/12, 上海交通大学医学院附属仁济医院,研究员

2010/10 – 2013/02, 浙江大学,海洋科学与工程学系, 副研究员

2010/10 – 2012/07, 美国普渡大学,药学院,访问教授(visiting assistant professor

2008/03 – 2010/05, 美国国立癌症研究院(NCI), 研究员(research scientist

2007/10 – 2008/02, 美国普渡大学,药学院,资深博士后(senior postdoctor

2005/07 – 2007/09, 美国俄勒冈州立大学,质谱分析中心, 博士后

 

 

三、学术任职

 

中国生物化学与分子生物学会海洋生物化学与分子生物学分会 常务理事

中国中药协会中药新技术专业委员会常务理事

美国毒理协会(SOT)会员

美国生药协会(American Society of Pharmacognosy)会员

杂志《Journal of Natural Products, 审稿人

湖南中医药大学 兼职教授

 

四、研究方向

 

主要从事海洋天然产物的分离提取,结构鉴定和构效关系,以及活性分子的系统生物学研究。作为第一或通讯作者在Organic lettersJournal of Organic ChemistryAnalytical ChemistryJournal of Proteome ResearchJournal of Natural Products等相关领域的重要期刊发表多篇学术论文。

在海外工作期间,深入开展了蛋白组学及代谢组学技术开发领域的研究。首次合成了同位素标记的生物素化学探针,利用迈克尔反应富集氧化脂蛋白组。并结合高分辨质谱定性和定量分析技术,从系统生物学的角度,对比分析了不同年龄段的大鼠心肌线粒体蛋白的脂质氧化修饰程度及脂质分子的作用位点。阐明了衰老与动物心肌线粒体蛋白脂质氧化的相互关系。该研究成果发表在分析化学及蛋白组学领域的国际权威杂志(Anal. Chem.2007793342-54J Proteome Res.20109, 4016-27J. Proteomics. 2012755724-33)。

 

 

五、承担课题

主持和主要参与的国内外研究项目:

1) 国家863计划海洋生物资源利用技术领域课题“饲料用海洋脂肪酶-单细胞蛋白联产关键技术及产品”经费:189万元,项目编号:2014AA093510主持,2014/01-2016/12

2) 国家自然科学基金面上项目“基于Keap1-Nrf2-ARE信号通路的活性先导化合物的发现及作用机制研究”经费:60万元,项目编号:81373321主持,2014/01-2017/12

3) 国家863计划课题“深海微生物分离培养与基因资源获取技术研究”经费:20万元,项目编号:2012AA092103骨干,2012/01-2015/12

4) 浙江省自然科学基金“浙江近海半丰满鞘丝藻的抗癌活性物质筛选、分离及结构分析”,(Y2100044,)(主持, 2010-2012

5) 浙江大学科研青年专项“浙江近海海洋蓝藻的抗癌活性物质筛选、分离及结构分析”(2010QNA4014)(主持,2010-2012

6) 项目:Mitochondrial Proteomics of the Aging Heart2007

资助: 美国国立卫生研究院(NIH)重大项目; 5R01AG025372-03(主要参与)

7) 项目:Neurotoxins from Marine Algae and Cyanobacteria2007

资助: 美国国立卫生研究院(NIH)重大项目; 5R01NS053398-07 (主要参与)

8) 项目:Lipidomic profile of endocannabinoids from neuronal cells2011

资助: 美国国立卫生研究院(NIH)项目; R21 DA024193 (主要参与)

 

六、发表论文(代表性)

1. Qiu-Ye Chai, Zhen Yang, Hou-Wen Lin,* and Bing-Nan Han*. Alkynyl-Containing Peptides of Marine Origin: A Review  Mar. Drugs 2016, 14, 216; doi:10.3390

2. Jian-Hong Gan, Wen-Zhen Hu, Hao-Bing Yu, Fan-Yang, Meng-Xue Cao, Hua-Jin Shi, Yong-Feng Kang* and Bing-Nan Han*. Three New Aaptamine Derivatives   from the South China Sea Sponge Aaptos aaptos. J. Asian Natural Products Research; 2015 17(12), 1231-1238

3. Kai-Xuan Zhan, Wei-Hua Jiao, Fan Yang, Jing Li, Shu-Ping Wang, Yu-Shan Li,Bing-Nan Han,*(共同通讯) and Hou-Wen Lin *. Reniochalistatins A–E, Cyclic Peptides from the Marine Sponge Reniochalina stalagmitis. J. Nat. Prod. ; 2014, 77 (12), pp 2678–2684

4. Shu-Juan Piao, Wei-Hua Jiao, Fan Yang, Yang-Hua Yi, Ying-Tong Di, Bing-Nan Han,*(共同通讯) and Hou-Wen Lin *. New Hippolide Derivatives, withProtein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Activity from the Marine Sponge Hippospongia lachne. Mar. Drugs; 2014, 12(7), 4096-4109

5. Shu-Juan Piao,Yun-Long Song,Wei-Hua Jiao,Fan Yang,§ Xiang-Fang Liu, Wan-Sheng Chen, Bing-Nan Han*(共同通讯), and Hou-Wen Lin*. Hippolachnin A, a New Antifungal Polyketide from the South China Sea Sponge Hippospongia lachne.Org. Lett.15 (14), 3526–35292013

6. Bingnan Han*, Rachel Wright, Yi Fang, Aaron Kirchoff, Vincent jo Davisson, Julia Chester and Eric Barker . Quantitative LC–MS/MS analysis of arachidonoyl amino acids in mouse brain with treatment of FAAH inhibitor. Analytical Biochemistry; 432(2),74-812013

7. Bingnan Han, Mike Hare and Claudia S. Maier. A differential “Bottom Up” proteomic strategy for the

site-specific identification and quantitation of endogenous oxylipid protein modifications. Journal of proteomics 75(18)5724-5733, 2012

8. Bingnan Han, Luke H. Stockwin, Chad Hancock, Sherry X. Yu, Melinda G. Hollingshead, and Dianne L. Newton. Proteomic Analysis of Nuclei isolated from cancer cell lines treated with Indenoisoquinoline NSC724998, a novel Top1 inhibitor. Journal of Proteome Research; 9(8), 4016-4027, 2010

9. Bingnan Han*, Harald Gross, Kerry L. McPhail, Doug Goeger, Claudia S. Maier,William H. Gerwick. Wewakamide A and guineamide G, cyclic depsipeptides from the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula. Journal of Microbiology and Biotechnology(IF: 1.4); 21(9)930-936, 2012

10. Bingnan Han, Uwe M. Reinscheid, William H. Gerwick, Harald Gross. The structure elucidation of isomalyngamide K from the marine cyanobacterium Lyngbya majuscula by experimental and DFT computational methods. Journal of Molecular structure(IF: 1.7); 989, 109-113, 2011

11. Chad N. Hancock,Luke H. Stockwin, Bingnan Han, Raymond D. Divelbiss, Jung Ho Jun, Sajay V Malhotra, Melinda G. Hollingshead and Dianne L. Newton. A copper chelate of thiosemicarbazone NSC689534 induces Oxidative/ER stress and inhibits tumor growth in vitro and in vivo. Free Radical Biology and Medicine(IF: 5.8); 50(1)110-21, 2011

12. Saini V, Hose CD, Monks A, Nagashima K, Han B, Newton DL, Millione A, Shah J, Hollingshead MG, Hite KM, Burkett MW, Delosh RM, Silvers TE, Scudiero DA, Shoemaker RH. Identification of CBX3 and ABCA5 as Putative Biomarkers for Tumor Stem Cells in Osteosarcoma. PLoS One(IF: 4.1); 7(8)e41401, 2012

13. Luke H. Stockwin, Bingnan Han, Maja A. Bumke, Sherry X. Yu, Melinda G. Hollingshead, Mahmoud A. ElSohly, Waseem Gul, Desmond Slade, Ahmed Galal, and Dianne L. Newton. Artemisinin dimeranti-cancer activity is mediated by heme-catalyzed ROS generation and ER stress Induction.International Journal of Cancer(IF: 5.4); 125(6), 1266-1275, 2009

14. Bingnan Han, Fred Stevens and Claudia S. Maier.  Design, Synthesis, and Application of a Hydrazide-Functionalized Isotope-Coded Affinity Tag (HICAT) for the Quantification of Oxylid Protein Conjugates. Anal. Chem.(IF: 5.8); 2007; 79(9); 3342-3354.

15. Juan Chavez, Jianyong Wu, Bingnan Han, Woon-Gye Chung, and Claudia S. Maier.  New Role for an Old Probe: Affinity Labeling of Oxylipid Protein Conjugates by N’-Aminooxymethylcarbonylhydrdrazino-D-biotin.  Anal. Chem.78 (19), 6847 -6854, 2006.

16. Ramaswamy AV, Flatt PM, Edwards DJ, Simmons, TL, Han B and Gerwick WH. The secondary metabolites and biosynthetic geneclusters of marine cyanobacteria. Applications in biotechnology. Frontiers in Marine Biotechnology  (2006), 175-224.

17. Bingnan Han, Harald Gross, Douglas E. Goeger, Susan L. Mooberry, and William H. Gerwick. Aurilides B and C, Cancer Cell Toxins from a Papua New Guinea Collection of the Marine Cyanobacterium Lyngbya majuscule. J. Nat. Prod.  2006, 69, 572-575.

18. 15Bingnan Han, Kerry L. McPhail, Harald Gross, Doug Goeger, Susan    Mooberry, and William H. Gerwick. Isolation and Structure of Five Lyngbyabellin Derivatives from a Papua New Guinea Collection of the Marine Cyanobacterium Lyngbya majuscule. Tetrahedron, 2005, 61, 11723-11729.

19. Bingnan Han, Doug Goeger, Claudia S. Maier, and William H. Gerwick. The Wewakpeptins, Cyclic Depsipeptides from a Papua New Guinea Collection of the Marine Cyanobacterium Lyngbyasemiplena. J. Org. Chem. , 2005, 70 (8), 3133

20. Bingnan Han, Kerry L. McPhail, Alessia Ligresti, Vincenzo Di Marzo, and William H. Gerwick. Semiplenamides A-G, Fatty Acid Amides from a Papua New Guinea Collection of the Marine Cyanobacterium Lyngabya semiplena. J. Nat. Prod., 2003, 66, 1364-1368.

21. Hao-Bing Yu, Yang Fan, Sun Fan, Guo-Yi Ma, Jian-Hong Gan, Wen-Zhen Hu, Bing-Nan Han, Wei-Hua Jiao, and Hou-Wen Lin. Cytotoxic aaptamine derivatives from the South China Sea sponge Aaptos aaptos.Journal of Natural Products, 77(9), pp 2124-2129, 2014/9/26.

22. Yang Fan, Yike Zou, Ru-Ping Wang, Hamann Mark T, Hong-Jun Zhang, Wei-Hua Jiao, Bing-Nan Han, Shao-Jiang Song, and Hou-Wen Lin. Relative and absolute stereochemistry ofdiacarperoxides: antimalarial norditerpene endoperoxides from, marine sponge Diacarnus megaspinorhabdosa.Marine Drugs, 12(8), pp 4399-4416, 2014/8.

23. Wei-Hua Jiao, Ting-Ting Xu, Hao-Bing Yu, Guo-Dong Chen, Xiao-Jun Huang, Yang Fan, Yu-Shan Li, Bing-Nan Han, Xiao-Yan Liu, and Hou-Wen Lin. Dysideanones A-C, Unusual Sesquiterpene Quinones from the South China Sea Sponge Dysidea avara. Journal of Natural Products, 77(2), pp 346-350, 2014/2.

24. Wei-Hua Jiao, Ting-Ting Xu, Hao-Bing Yu, Feng-Rong Mu, Jia Li, Yu-Shan Li, Fan Yang, Bing-Nan Han, and Hou-Wen Lin. Dysidaminones A–M, cytotoxic and NF-kB inhibitory sesquiterpene aminoquinones from the South China Sea sponge Dysidea fragilis.RSC Advances, 4(18), pp 9236-9246, 2014/1/20.

25. Wei-Hua Jiao, Li Jing, Liu Qian, Ting-Ting Xu, Guo-Hua Shi, Hao-Bing Yu, Yang Fan, Bing-Nan Han, Li Min, and Hou-Wen Lin. Dysidinoid A, an Unusual Meroterpenoid with Anti-MRSA Activity from the South China Sea Sponge Dysidea sp.Molecules, 19(11), pp 18025-18032, 2014.

26. Yan Min, Zhu Yan, Hong-Jun Zhang, Wei-Hua Jiao, Bing-Nan Han, Zhao-Xi Liu, Qiu Feng, Wan-Sheng Chen, and Hou-Wen Lin. Anti-inflammatory secondary metabolites from the leaves of Rosa laevigata. BIOORGANIC & MEDICINAL CHEMISTRY, 21(11), pp 3290-3297, 2013