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521人才

付彩云

发表于:2018-01-24  浏览人数:

142327198102170023

付彩云

别:女

出生年月:19812

称:副教授

生物化学与分子生物学

室: 6-305

话: 18958140889

电子邮件:fucy03@126.com

主要学习工作经历

1. 1999.09-2003.06 兰州大学生命科学学院生物学基地班,学士 (班主任:张迎梅教授)

2. 2003.09-2008.06 兰州大学生命科学学院生物化学与分子生物学研究所,硕博连读,理学博士(导师:王锐教授)

3. 2008.12-至今 浙江理工大学,生命科学学院讲师,副教授

4. 2013.10-2014.01 墨尔本Peter MacCallum Cancer Centre访问学者

主要学术及社会兼职

1. 中国转化医学联盟 理事兼副秘书长

2. 中国医药生物技术协会转化医学分会 委员兼秘书

3. 浙江省转化医学学会 理事秘书

4. 浙江省细胞生物学会 理事秘书

5. 浙江省分析测试协会细胞与生化专业委员会 委员

6. 浙江省转化医学学会青委会 委员

主要研究方向

1. 小分子靶向药研发与肿瘤靶向治疗

2. 多肽药理学

获奖与荣誉

1. 2012年入选浙江理工大学国际化“中青年拔尖人才”引领计划

2. 2013年入选浙江省第一批“青年科学家”培养计划

3. 2014年入选浙江省“新世纪151人才工程”培养计划

4. 2015年获浙江省转化医学学会优秀理事荣誉称号

5. 2016年获教育部颁发的霍英东教育基金会第十五届高等院校青年教师奖

6. 连续三届指导本科生获“挑战杯”全国大学生课外学术科技作品竞赛金奖、银奖和二等奖等;指导本科生获浙江省第六届大学生生命科学竞赛一等奖;指导本科生团队多次获金富春创新创业奖学金;指导学团制学生获10余项“新苗人才”计划项目支持;培养研究生获“浙江省普通高校优秀毕业生”荣誉称号;本人连续多年被评为浙江理工大学优秀毕业论文指导教师,以及多次获浙江理工大学教学育人先进奖、科协先进工作者、优秀班主任等多种荣誉称号。

科研教学项目

1. 哺乳动物速激肽hemokinin-1的中枢镇痛位点和镇痛机制研究(项目编号31000496),国家自然科学基金青年基金,21万元,2011.1-2013.12,排名1/9,主持结题;

2. 靶向阻断神经激肽受体抑制白血病细胞生长的分子机制及其在白血病治疗中的潜在价值(项目编号31470071,国家自然科学基金面上项目,30万元,2015.1-2016.12,排名1/10,主持在研;

3. 沙瑞度坦抑制人粒性白血病细胞增殖的靶点蛋白筛选及其功能研究(项目编号LY14C050003),浙江省自然科学基金面上项目,8万元,2014.01-2016.12,排名1/5,主持在研;

4. Neurokinin Receptors激动剂诱导小鼠红白血病细胞MEL分化的作用及调控研究(项目编号Y200909697),浙江省教育厅项目,厅局级,1.2万元,2009.12-2011.12,排名1/6,主持结题。

专著论文

1. Lu Y, Zhang TF, Shi Y, Zhou HW, Chen Q, Wei BY, Wang X, Yang TX, Chinn YE, Kang J, Fu CY*. PFR peptide, one of the antimicrobial peptides identified from the derivatives of lactoferrin, induces necrosis in leukemia cells. Scientific Reports. 2016, 6: 20823. (corresponding author)

2. Zou Y, Guo CG, Yang ZG, Sun JH, Zhang MM*, Fu CY*. A small interfering RNA targeting vascular endothelial growth factor efficiently inhibits growth of VX2 cells and VX2 tumor model for hepatocellular carcinoma in rabbit by transarterial embolization-mediated siRNA delivery. Drug Design, Development and Terapy, 2016, 10: 1243-1255. (corresponding author)

3. Fang WJ*, Fu CY*, Chen XG, Mou XZ, Liu FL, Qian H, Zhao P, Zheng YL, Zheng Y, Deng J, Ye PJ, Wang YF, Zheng SS. Neurokinin-2 receptor polymorphism predicts lymph node metastasis in colorectal cancer patients. Oncology Letters, 2015, 9: 2003-2006. (co-first anthor)

4. Zhu XC, Zhang JL, Ge CT, Yu YY, Wang P, Yuan TF*, Fu CY*. Advances in cancer pain from bone metastasis. Drug Design, Development and Terapy, 2015, 9: 4239-4245. (corresponding author)

5. Zhu XC, Ge CT, Wang P, Zhang JL, Yu YY, Fu CY*. Analgesic effects of lappaconitine in leukemia bone pain in a mouse model. PeerJ, 2015, 3:e936. (corresponding author)

6. Fu CY*, Xia RL, Zhang TF, Lu Y, Zhang SF, Yu ZQ*, Jin T, Mou XZ*. Hemokinin-1(4-11)-induced analgesia selectively up-regulates δ-opioid receptor expression in mice. PLoS ONE, 2014, 9(2): e90446. (corresponding author)

7. Fu CY1, Chen W1, Jin YT*. The complete mitochondrial genome of Phrynocephalus guinanensis (Reptilia, Squamata, Agamidae). Mitochondrial DNA2014 1-2.

8. Xia RL, Lu Y, Zhu LN, Zhang SF, Zhao FK, Fu CY*. Different regulatory pathways are involved in the proliferative inhibition of two types of leukemia cell lines induced by paclitaxel. Oncology Reports, 2013, 30: 1853-1859. (corresponding author)

9. Zhu LN, Fu CY*, Zhang SF, Chen W, Jin YT, Zhao FK. Novel cytotoxic exhibition mode of antimicrobial peptide anoplin in MEL cells, the cell line of murine Friend leukemia virus- induced leukemic cells. Journal of Peptide Science, 2013, 19: 566-574. (corresponding author)

10. Xia RL, Fu CY*, Zhang SF, Jin YT, Zhao FK. Study on the distribution sites and the molecular mechanism of analgesia after intracerebroventricular injection of rat/mouse hemokinin-1 in mice. Peptides, 2013, 43: 113-120. (corresponding author)

11. Fu CY, Zhao YL, Dong L, Chen Q, Ni JM*, Wang R*. In vivo characterization of the effects of human hemokinin-1 and human hemokinin-1(4-11), mammalian tachykinin peptides, on the modulation of pain in mice. Brain, Behavior, and Immunity, 2008, 22: 850-860.

12. Fu CY, Kong ZQ, Long Y, Chen Q, Wang R*. Cardiovascular responses to rat/mouse hemokinin-1, a mammalian tachykinin peptide: Systemic study in anesthetized rats. European Journal of Pharmacology, 2007, 572 175–181.

13. Fu CY, Tang XL, Yang Q, Chen Q, Wang R*. Effects of rat/mouse hemokinin-1, a mammalian tachykinin peptide, on the antinociceptive activity of pethidine administered at the peripheral and supraspinal level. Behavioural Brain Research, 2007, 184: 39–46.

14. Fu CY, Yang Q, Wang KR, Kong ZQ, Chen Q, Wang R*. Rat/mouse hemokinin-1, a mammalian tachykinin peptide, markedly potentiates the antinociceptive effects of morphine administered at the peripheral and supraspinal level. Behavioural Brain Research, 2006, 170: 293–301.

15. Fu CY, Kong ZQ, Wang KR, Yang Q, Zhai K, Chen Q, Wang R*. Effects and mechanisms of supraspinal administration of rat/mouse hemokinin-1, a mammalian tachykinin peptide, on nociception in mice. Brain Research, 2005, 1056: 51–58.

16. Long Y1, Fu CY1, Tian XZ, Chen J, Han M, Wang R*. Mechanisms of relaxing response induced by rat/mouse hemokinin-1 in porcine coronary arteries: Roles of potassium ion and nitric oxide. European Journal of Pharmacology, 2007, 569: 119125. (co-first anthor)

17. Kong ZQ1, Fu CY1, Chen Q, Wang R*. Cardiovascular responses to intravenous administration of human hemokinin-1 and its truncated form hemokinin-1(4-11) in anesthetized rats. European Journal of Pharmacology, 2008, 590: 310316. (co-first anthor)

18. Chang HN, Liu BY, Qi YK (Qi, Yun-Kun), Zhou Y, Chen YP, Pan KM, Li WW, Zhou XM, Ma WW, Fu CY, Qi YM, Liu L, Gao YF. Blocking of the PD-1/PD-L1 Interaction by a D-Peptide Antagonist for Cancer Immunotherapy. Angewandte Chemie-International Edition, 2015, 54: 11760-11764

其他(已授权国家发明专利)

1. 专利授权号:ZL 2011 1 0070470.1;申请人:浙江理工大学;发明创造名称:神经激肽受体拮抗剂在制备抗癌药物中的用途;发明人:付彩云 赵辅昆 张世馥 王宇沙 陈攀峰。(已转让

2. 专利授权号:ZL 2011 1 0070497.0;申请人:浙江理工大学;发明创造名称:SR140333的抗血癌作用;发明人:付彩云 赵辅昆 张世馥 王宇沙 陈攀峰。

3. 专利授权号:ZL 2012 1 0323180.8;申请人:浙江理工大学;发明创造名称:神经激肽受体2的拮抗剂在白血病治疗中的用途;发明人:付彩云 夏瑞龙 赵辅昆 张世馥 陈攀峰 王宇沙。

4. 专利授权号:ZL 2013 1 0069107.7;申请人:浙江理工大学;发明创造名称:蜂毒抗菌肽Anoplin在食管癌治疗中的用途;发明人:付彩云,卢燕,朱丽娜,赵辅昆,张世馥。(已转让

5. 专利授权号:ZL 2013 1 0068642.0;申请人:浙江理工大学;发明创造名称:蜂毒抗菌肽Anoplin在肝癌治疗中的用途;发明人:付彩云,卢燕,朱丽娜,赵辅昆,张世馥。

6. 专利授权号:ZL 2013 1 0069106.2;申请人:浙江理工大学;发明创造名称:蜂毒抗菌肽Anoplin在血癌治疗中的用途;发明人:付彩云,卢燕,朱丽娜,赵辅昆,张世馥。