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521人才

杜志游

发表于:2018-01-24  浏览人数:

杜志游

别:男

出生年月:1978 11

称:副教授,博士

微生物学

室: 6号楼433

话: 0571-86843195

电子邮件:du.zhiyou@gmail.com

主要学习工作经历

1. 2009.10-2011.09 剑桥大学 玛丽居里研究员

2. 2007.04- 浙江理工大学 副研究员

3. 2001.09-2006.09 浙江大学 微生物学博士

4. 1997.09-2001.06 温州师范学院 生物科学本科

主要学术及社会兼职

1. 浙江省政府应急管理专家

2. American Society for Virology, Associate member

3. Advance of International plant virus, Associate member

4. 生命科学学院青年教师联谊会副理事长

荣誉

1.浙江省151人才第三层次

2.浙江理工大学首批521中青年拔尖人才

主要研究方向

1. 病毒分子特性研究:以模式病毒黄瓜花叶病毒CMV作为研究对象,利用分子生物学、生化和遗传等技术分析CMV 2b蛋白介导的病毒致病性。

2. 病毒与寄主的分子互作:以模式植物拟南芥和CMV作为研究对象,研究病毒与寄主的分子互作,包括植物的抗病毒免疫和病毒的致病。

3. 病毒-植物-昆虫介体的三者互作:蚜虫传播是CMV在自然条件下的主要传播方式。课题组于2011年申请获得国家自然科学基金项目“卫星RNA和协生病毒与CMV的互作对CMV诱导拟南芥抗蚜虫反应的影响及其途径”。

4. 抗病毒新技术新方法:我们在研究CMV与寄主互作的基础上,通过分子生物学和正反向遗传技术开展有关抗病毒新技术和新方法的探索性工作。

科研教学项目

1. 卫星RNA和协生病毒与CMV的互作对CMV诱导拟南芥抗蚜虫反应的影响及其途径”,国家自然科学基金,2012.01-2015.12(负责人)

2. Subversion of Insect Resistance: A novel Role for a Plant Viral Silencing Suppressor European CommissionMarie Curie International Incoming Fellowship2009.10- 2011.09(负责人)

3.“CMV 2b蛋白致病关键氨基酸在RNA沉默通路中的作用方式和靶位国家自然科学基金, 2009.01-2011.12(负责人)

4. 外源AGO1蛋白特定片段对CMV 2b蛋白抗RNA沉默活性的干扰研究”,浙江省自然科学基金,2009.1- 2010.12(负责人)

5. 蜂源性降血压功能肽高效表达基因的筛选及优化国家高技术发展研究计划(863计划)2008.1- 2010.12(副组长,负责子课题)

6.植物病毒的快速检测与新病毒的基因组研究,国家自然科学基金, 2006.1- 2008.12, 8万(参与,3/7

7.黄瓜花叶病毒2b蛋白致病性对病毒适应性的影响,浙江理工大学博士科研启动基金,2007.01-2008.12 (负责人)

专著论文

1. Du Z*, Chen A, Chen W, Liao Q, Zhang H, Bao Y, Roossinck MJ, Carr JP. Nuclear-cytoplasmic partitioning of the Cucumber mosaic vius 2b protein determines the balance between its roles as a virulence determinant and RNA silencing sppressor. Journal of Virology, 2014 doi:10.1128/JVI.00284-14. Top Journal

2. Du Z*, Chen A, Chen W, Westwood J, Baulcombe DC, Carr JP*. Using viral vector to reeal therole of microRNA159 in disease symptom induction by a severe strain of Cucumber mosaic virus. Plant Physiology, 2014, 164:1378-1388. Top Journal

3. Westwood JH, Groen SC, Du Z, et al. A trio of viral proteins tunes Aphid-plant interactions in Arabidopsis thaliana. PLoS One 8(12):e83066.

4. Xu A, Zhao Z, Chen W, Liao Q, Chen J, Carr JP, Du Z*. Self-interaction of the cucumber mosaic virus 2b protein plays a vital role in suppression of RNA silencing and induction of viral symptoms. Molecular Plant Pathology. 2013. 14(8):803-812

5. Li C, Du Z, Chen J. Structural and functional elucidation of AGO proteins. Chinese Journal of Biochemistry and Molecular Biology, 2009, 25(11): 969-976.

6. Li L, Tian Q, Du Z, Duns GJ, Chen J. A novel double-stranded RNA virus detected in Primula malacoides is a a plant-isolated partitivirus closely related to partitivirus infecting fungal species. Archive Virology, 2009, 164(4): 565-572.

7. Du Z, Chen F, Zhao Z, Liao Q, Palukaitis P, Chen J. The 2b protein and the C-terminus of the 2a protein of cucumber mosaic virus subgroup I strains both play a role in viral RNA accumulation and induction of symptoms. Virology 2008, 380: 363-370.

8. Liao Q-S, Du Z-Y, Zhang H-R, Wu P, Zhu L-P, Chen J-S. Construction of infectious clone for cucumber mosaic virus pepper isolate. Scientia Agricultura Sinica 2008, 41(7): 1975-1982. (In Chinese)

9. Du Z-Y, Chen F-F, Liao Q-S, Zhang H-R, Chen Y-F, Chen J-S. The 2b ORFs encoded by subgroup IB strains of Cucumber mosaic virus induce different virulence on Nicotiana species. Journal of General Virology 2007, 88: 2596-2694.

10. Du Z, Jin B, Liu W, Chen L, Chen J. Highly sensitive fluorescent-labeled probes and glass slide hybridization for the detection of plant RNA viruses and a viroid. Acta Biochimica et Biophysica Sinica 2007, 39(5): 326-334.

11. Chen Y, Chen J, Zhang H, Tang X, Du Z. Molecular evidence and sequence analysis of a natural reassortant between Cucumber mosaic virus subgroup IA and II strains. Virus Genes 2007, 35: 405-413.

12. Liao Q, Zhu L, Du Z, Zeng R, Peng J, Chen J. Satellite RNA-mediated reduction of cucumber mosaic virus genomic RNAs accumulation in Nicotiana tabacum. Acta Biochimica et Biophysica Sinica 2007, 39(3):217-23.

13. Chen F-F, Du Z-Y, Liu X, Xie L, Chen J-S. Effect of Cucumber mosaic virus-encoded 2b protein on Photosynthesis and chloroplast structure of the host plant. Progress in Biochemistry and Biophysics 2007, 34(8): 889-896. (In Chinese)

14. Liao Q-S, Du Z-Y, Zhang H-R, Zhu L-P., Wu P, Chen J-S. Necrosis pathotype induced on Nicotiana glutinosa by infection of CMV-Cb7 related to RNA2. Progress in Biochemistry and Biophysics 2007, 34(8): 824-829. (In Chinese)

15. Lang Q-L, Chen J-S, Fu T-Z, Du Z-Y. Occurrence and molecular detection of Potato virus S (PVS) in Zhejiang province. Acta Phytopathology Sinica 2007, 32(2): 217-220. (In Chinese)

16. Du Z, Chen J, Hiruki C. Optimization and application of a multiplex RT-PCR for simultaneous detection of five potato viruses using 18S rRNA as an internal control. Plant Disease 2006, 90(2): 185-189.

17. Feng J, Chen S, Tang X, Ding X, Du Z, Chen J. Quantitative determination of cucumber mosaic virus genome RNAs in virions by real-time reverse transcription-polymerase chain reaction. Acta Biochimica et Biophysica Sinica 2006, 38(10):669-676.

18. Gu Y, Du Z-Y, Lang Q-L, Chen J-S, He N-Y. Detection of Potato Spindle Tuber Viroid Using RNA Hybridized Chips. Chemical Research in Chinese Universities 2006, 27(11):2106-2109. (In Chinese)

19. Du Z-Y, Chen J-S. Identification and grouping study of Potato virus X Hunan isolate. Virologica Sinica 2003, 18(2):119-123. (In Chinese)

20. Dong X-J*, Du Z-Y, Chen Z. Decolorization of Direct Black 22 by Aspergillus ficuum. Journal of Environmental Sciences 2001, 12(4): 472-475.

其他