金甲，博士，
副教授，硕士生导师
生物制药系副主任
地址：浙江省杭州市钱塘新区2号大街928号
E-mail ：aukaukauk@163.com; jjin@zstu.edu.cn
所在学科组：生物制药 办公室：6-417
主要研究方向: 药物化学、生物医用材料
金甲副教授主要从事药物小分子、多肽的结构改造和生物医用材料开发研究，并探索其在肿瘤、代谢等疾病治疗中的作用。近年来，在包括JACS、PNAS、Diabetes、Theranostics、JMC、EJMC、IJBM等top期刊发表学术论文，单篇引用超过100次，申请专利16项，已获授权12项，转让2项。主持国家自然科学基金，浙江省自然科学基金等项目，受邀JACS、JMC等多个国际顶级期刊审稿，兼任浙江理工大学生命科学与医药学院——嘉兴市第一医院联合研究中心主任，中国药学会生化与生物技术药物专业委员会青年委员，中国化学会高级会员。指导本科生在全国大学生生命科学竞赛、全国大学生生命科学创新创业大赛等多项竞赛中获奖，指导硕士研究生28人，其中多人分赴巴黎城市大学、中国科技大学、华东师范大学和浙江工业大学读博深造。
教育及研究经历：
2003.9～2007.6 上海师范大学 化学工程与工艺 工学学士
2007.9～2010.6 上海师范大学 有机化学 理学硕士 （导师：薛思佳教授）
2010.9～2013.6 华东师范大学 有机化学 理学博士 （导师：杨帆教授，汤杰教授；合作导师：李静雅研究员，李佳研究员）
2019.4～2020.7 加州大学旧金山分校 药物化学系 访问学者 （合作导师，William F. DeGrado/美国科学院院士、美国艺术与科学院院士）
主要学术与社会兼职：
中国药学会会员，中国化学会会员，浙江理工大学生命科学与医药学院——嘉兴市第一医院联合研究中心主任，JACS等多个SCI期刊审稿人
主持和参与科研项目及课题：
1. 国家自然科学基金青年基金项目:“新型选择性CARM1抑制剂的设计、合成及生物活性研究”（NO.81803339，主持）
2. 浙江省自然科学基金探索项目：“辅激活相关精氨酸甲基转移酶蛋白降解剂的设计、合成与抗肿瘤活性研究”（NO.LY23H300004，主持）
3. 浙江省公益技术研究工业项目:“新型抗菌复合可吸收止血微球产业化关键技术研究”（NO.2016C31017，主持）
4. 浙江理工大学基本科研项目：“CARM1蛋白降解剂的设计、合成和活性研究”（NO.23042124-Y，主持）
5. 浙江理工大学青年创新专项：“新型仿血小板生物止血材料的关键制备技术和应用研究”（NO.19042223-Y，主持）
6. 国家自然科学基金项目：“靶向menin-MLL相互作用界面的药物发现与药物设计”（NO.81402849，参与）
7. 国家自然科学基金项目：“新型PRMT1选择性抑制剂的设计、合成及抗实体瘤活性研究”（NO.82373729，参与）
8. 国家自然科学基金项目：“（Z）型四氢嘧啶类昆虫乙酰胆碱受体抑制剂的分子设计及先导化合物优化研究”（NO.21042010，参与）
9. 浙江省自然科学基金一般项目：“针对蛋白质精氨酸甲基转移酶PRMT1的药物发现与化学干预研究”（NO. LY18H300008，参与）
10. 浙江省科技厅公益技术应用研究项目：“基于金黄色葡萄球菌ClpP的抗菌药物发现与药物设计”（NO. 2015C33159，参与）
11. 主持其他横向委托课题十多项，参与十多项。
发表文章
1. Yi Wang, Zeyu Ma, Yingjing Li, Hongyan Yang, Jia Jin, Yuxia Jin, and Guobao Zhou*. S9. 6 Antibody-Mediated Wireless Portable Biosensor with Multiple Affinity Enhancements for Comprehensive Detection of Nucleic Acid in Serum. Analytical Chemistry, 2025, 97,9386-9394. (Top Journal)
2. Y Xu, Z Zhang, C Wei, J Jin, K Zhang, L Cai*. Strategic Synthesis of γ-Nitroketones between Nitroalkanes and Cyclopropanols: Harnessing Free-Radical Nucleophilic Substitution for Chemical Innovation. Organic Letters, 2025, 27(13), 3111-3116. (Top Journal)
3. R Wang, B Guan, W Wang, H Yan, J Jin, Y Yang, L Li, L Guo, Y Zeng*. Colorimetric and photothermal dual-mode aptasensor for ultrasensitive detection of tobramycin based on Mn-CeO2 nanozyme with one-pot hydrothermal method. Sensors and Actuators B: Chemical, 2025, 427, 137178. (Top Journal)
4. Y Li, Z Hou, Z Xiao, C Lu, J Jin, Y He, J Jin, K Suntharalingam. Modulating the Anticancer Activity of Square‐Planar Platinum (II) Complex by Its Chelated Diphosphine. Applied Organometallic Chemistry, 2025, 39 (2), e7803.
5. Xin Chen, Fulin Luo, Mengting Yuan, Chongbin Bai, Qian Chen, Kui Zhang, Yaohua Fan, Chenxi Cao, Lei Wang, Fei Ye, Jia Jin*. Alginate/chitosan-based hemostatic microspheres loaded with doxorubicin liposomes for postoperative local drug delivery in solid tumor. International Journal of Biological Macromolecules. 2024, 282, 137090. (Top Journal)
6. ZY Ma, XF Zhang, YZ Hu, MD Zhu, J Jin, P Qian*. Comparison of staining quality between rapid and routine hematoxylin and eosin staining of frozen breast tissue sections: an observational study. Journal of International Medical Research. 2024, 52 (6), 03000605241259682.
7. Chenyu Liu, Yang Li, Zhihao Liu, Chenxi Cao, Min Lin, Xin Chen, Mengting Yuan, Yaohua Fan, Xiaodong Gu, Lei Wang, Fan Yang*, Fei Ye*, Jia Jin*. Structure-based discovery of potent CARM1 inhibitors for colorectal cancer therapy. European Journal of Medicinal Chemistry. 2024, 269, 116288. (Top Journal)
8. Zhihao Liu, Min Lin, Chenyu Liu, Xin Chen, Qian Chen, Xinyu Li, Xiaoyan Wu, Yahui Wang, Lei Wang, Fan Yang, Cheng Luo, Jia Jin*, Fei Ye*. Development of (2-(Benzyloxy) phenyl) methanamine Derivatives as Potent and Selective Inhibitors of CARM1 for the Treatment of Melanoma. Journal of Medicinal Chemistry. 2024 67 (8), 6313-6326. (Top Journal)
9. S Zhang, X Jia, Q Wu, J Jin, L Xu, L Yang, J Han, Q Zhou*. The involvement of the gut microbiota in postoperative cognitive dysfunction based on integrated metagenomic and metabolomics analysis. Microbiology Spectrum, 2023 11 (6), e03104-23.
10. Jing Xu, Yiran Wang, Jiali Zhang, Amr Abbas Abdelmoneim, Zhongjie Liang, Lei Wang, Jia Jin, Qi Dai, Fei Ye*. Elastic network models and molecular dynamic simulations reveal the molecular basis of allosteric regulation in ubiquitin-specific protease 7 (USP7). Computers in Biology and Medicine, 2023, 162, 107068.
11. Xiao Li, Fei Li, Fei Ye, Haotian Guo, Wentao Chen, Jia Jin, Yiran Wang, Pengfei Dai, Huili Shi, Hongru Tao, Wenzhen Dang, Yiluan Ding, Mingchen Wang, Hualiang Jiang, Kaixian Chen, Naixia Zhang, Dong Gao, Yuanyuan Zhang*, Cheng Luo*. Spermine is a natural suppressor of AR signaling in castration-resistant prostate cancer. Cell Reports. 2023, 42 (7). (Top Journal)
12. J Liu, J Jin, K Zhang, L Cai*. Alkoxy Radical Induced Transformations from N‐Alkoxyphthalimides Under the Photoredox Catalysis. Asian Journal of Organic Chemistry, 2023, 12 (7), e202300160.
13. K Zhang, C Wei, Y Li, Y Yao, L Song, J Jin, L Cai*. Cu (OAc) 2-catalyzed hydrazination of cyclopropanols and late-stage transformation to 4, 5-dihydropyrazoles. New Journal of Chemistry, 2023, 47 (8), 3653-3657.
14. Fei Ye*, Min Lin, Jia Jin, Sylvain Broussy*. Computer-aided drug design: Drug discovery, computational modelling, and artificial intelligence. Frontiers in Chemistry, 2022, 10, 968687.
15. Haofeng Hu, Fulin Luo, Qian Zhang, Ming Xu, Xin Chen, Zhihao Liu, Haodong Xu, Lei Wang, Fei Ye, Kui Zhang, Bin Chen, Song Zheng, Jia Jin*. Berberine coated biocomposite hemostatic film based alginate as absorbable biomaterial for wound healing. International Journal of Biological Macromolecules, 2022, 209, 1731-1744. (Top Journal)
16. Weiwei Zeng, Nga-man Cheng, Xia Liang, Haofeng Hu, Fulin Luo, Jia Jin* & Ya-wei Li*. Electrospun polycaprolactone nanofibrous membranes loaded with baicalin for antibacterial wound dressing. Scientific Reports, 2022, 12, 10900.
17. Xiao Li, Lun Zhang, Jing Xu, Chenyu Liu, Xiaojian Zhang, Amr Abbas Abdelmoneim, Qian Zhang, Jiaqi Ke, Yingnan Zhang, Lei Wang, Fan Yang, Cheng Luo, Jia Jin* and Fei Ye*. Identification, Synthesis, and Biological Evaluations of Potent Inhibitors Targeting Type I Protein Arginine Methyltransferases. Journal of Chemical Information and Modeling, 2022, 62, 692-702.
18. Ketaki D. Belsare, Haifan Wu, Dibyendu Mondal, Annalise Bond, Erika Castillo, Jia Jin, Hyunil Jo, Addison E. Roush, Kala Bharath Pilla, Andrej Sali, Carlo Condello, and William F. DeGrado*. Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ. PNAS, 2022, 119, e2114486119. (Top Journal)
19. Qian Zhang, Lun Zhang, Jia Jin, Yaohua Fan, Xiaoguang Wang, Haofeng Hu, Xiaoqing Ye, Lei Wang, Chenxi Cao*, Fei Ye*. Identification of PRMT5 inhibitors with novel scaffold structures through virtual screening and biological evaluations. Journal of Molecular Modeling, 2022, 28(7), 1-9.
20. Aurelio J. Dregni, Harrison K. Wang, Haifan Wu, Pu Duan, Jia Jin, William F. DeGrado, and Mei Hong*. Inclusion of the C‑Terminal Domain in the β‑Sheet Core of Heparin-Fibrillized Three-Repeat Tau Protein Revealed by Solid-State Nuclear Magnetic Resonance Spectroscopy. Journal of the American Chemical Society, 2021, 143, 7839-7851. (Top Journal)
21. Lei Wang*, Meng Xu, Haofeng Hu, Lun Zhang, Fei Ye, Jia Jin, Hongming Fang, Jian Chen, Guiqian Chen, Sylvain Broussy, Michel Vidal, Zhengbing Lv, Wang-Qing Liu*. A Cyclic Peptide Epitope of an Under-Explored VEGF-B Loop 1 Demonstrated In Vivo Anti-Angiogenic and Anti-Tumor Activities. Frontiers in pharmacology, 2021, 12, 734544.
22. Jianfeng Wang1, Chen Wang1, Pan Xu1, Xiao Li, Yongning Lu, Di Jin, Xiaomao Yin, Hao Jiang, Jing Huang, Huan Xiong, Fei Ye, Jia Jin, Yu Chen, Yiqian Xie, Zhifeng Chen, Hong Ding, Hao Zhang, Rongfeng Liu, Hualiang Jiang, Kaixian Chen, Zhiyi Yao, Cheng Luo*, Yiran Huang*, Yuanyuan Zhang*, Jin Zhang*. PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma. Theranostics, 2021, 11(11): 5387. (Top Journal)
23. Xiaojian Zhang, Kaili Dai, Chenyu Liu, Haofeng Hu, Fulin Luo, Qifan Qi, Lei Wang, Fei Ye, Jia Jin*, Jie Tang*, and Fan Yang*. Berberine-Coated Biomimetic Composite Microspheres for Simultaneously Hemostatic and Antibacterial Performance. Polymers, 2021, 13(3), 360.
24. Jia Jin*, Ming Xu, Yixuan Liu, Zhixiao Ji, Kaili Dai, Lun Zhang, Lei Wang, Fei Ye, Gang Chen*, Zhengbing Lv*. Alginate-based composite microspheres coated by berberine simultaneously improve hemostatic and antibacterial efficacy. Colloids and Surfaces B: Biointerfaces, 2020, 194, 111168. (Top Journal)
25. X Ye, G Chen, J Jin, B Zhang, Y Wang, F Ye. The development of inhibitors targeting the mixed lineage leukemia 1 (MLL1)-WD repeat domain 5 protein (WDR5) protein-protein interaction. Current Medicinal Chemistry, 2020.
26. H Jiang, J Jin, Y Duan, Z Xie, Y Li, A Gao, M Gu, X Zhang, C Peng, C Xia, ... Mitochondrial uncoupling coordinated with PDH activation safely ameliorates hyperglycemia via promoting glucose oxidation. Diabetes, 2019, 68 (12), 2197-2209. (Top Journal)
27. J Jin*, X Ye, D Boateng, K Dai, F Ye, P Du, H Yu*. Identification and characterization of potent and selective inhibitors targeting protein tyrosine phosphatase 1B (PTP1B). Bioorganic & Medicinal Chemistry Letters, 2019, 29 (16), 2358-2363
28. X Ye, R Zhang, F Lian, W Zhang, W Lu, J Han, N Zhang, J Jin, C Luo*, ... The identification of novel small-molecule inhibitors targeting WDR5-MLL1 interaction through fluorescence polarization based high-throughput screening. Bioorganic & medicinal chemistry letters, 2019, 29 (4), 638-645.
29. W Wu, T Liu, H He, X Wu, X Cao, J Jin, Q Sun, VAL Roy, RKY Li. Rhelogical and antibacterial performance of sodium alginate/zinc oxide composite coating for cellulosic paper. Colloids and surfaces B: Biointerfaces, 2018, 167, 538-543. (Top Journal)
30. Jia Jin*, Zhixiao Ji, Ming Xu, Chenyu Liu, Xiaoqing Ye, Weiyao Zhang, Si Li, Dan Wang, Wenping Zhang, Jianqing Chen, Fei Ye*, Zhengbing Lv*. Microspheres of Carboxymethyl Chitosan, Sodium and Collagen as a Hemostatic Agent in vivo. ACS Biomaterials Science & Engineering, 2018, 4, 2541-2551.
31. Fei Ye*, Weiyao Zhang, Xiaoqing Ye, Jia Jin, Zhengbing Lv, and Cheng Luo*. Identification of Selective, Cell Active Inhibitors of Protein Arginine Methyltransferase 5 through Structure-Based Virtual Screening and Biological Assays. Journal of Chemical Information and Modeling, 2018, 58, 1066-1073.
32. Fei Ye1, Xiangqian Kong1, Hao Zhang, Yan Liu, Zhiyuan Shao, Jia Jin, Yi Cai, Rukang Zhang, Linjuan Li, Yang W. Zhang, Yu-Chih Liu, Chenhua Zhang, Wenbing Xie, Kunqian Yu, Hong Ding, Kehao Zhao, Shijie Chen*, Hualiang Jiang, Stephen B. Baylin* and Cheng Luo*. Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNMT1, ACS Chemical Biology, 2018, 13, 772-781.
33. Wang, Chen1 ; Jiang, Hao1 ; Jin, Jia1; Xie, Yiqian; Chen, Zhifeng; Zhang, Hao; Lian, Fulin; Liu, Yu-Chih; Zhang, Chenhua; Ding, Hong; Chen, Shijie; Zhang, Naixia; Zhang, Yuanyuan ; Jiang, Hualiang; Chen, Kaixian; Ye, Fei*; Yao, Zhiyi*; Luo, Cheng*. Development of potent type i protein arginine methyltransferase (PRMT) inhibitors of leukemia cell proliferation, Journal of Medicinal Chemistry, 2017.10.11, 60(21): 8888~8905. (Co-first author, Top Journal)
34. Zhang, weiyao1; Lu, wenchao1; Jiang, hao; Lv, zhengbing; Xie, yiqian; Lian, fulin; Liang, zhongjie; Jiang, yuxi; Wang, dajin; Luo, chen; Jin, Jia*; Ye, fei*. Discovery of alkyl bis (oxy) dibenzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors, Chemical Biology & Drug Design, 2017.7.19, 90(6): 12601270.
35. Xinyi Shi, Qiang Fang, Miao Ding, Jing Wu, Fei Ye, Zhengbing Lv and Jia Jin*. Microspheres of carboxymethyl chitosan, sodium alginate and collagen for a novel hemostatic in vitro study, Journal of Biomaterials Applications. 2016, 30, 1092–1102.
36. Haibing He, Yinghua Ge, Hong Dai, Song Cui, Fei Ye, Jia Jin*, Yujun Shi*. Design, synthesis and biological evaluation of stilbene derivatives as novel inhibitors of protein tyrosine phosphatase 1B, Molecules, 2016, 21(12): 1722-1733.
37. Fei Ye, Weiyao Zhang, Wenchao Lu, Yiqian Xie, Hao Jiang, Jia Jin*, Cheng Luo*. Identification of novel inhibitors against coactivator associated arginine methyltransferase 1 based on virtual screening and biological assays, Biomed Research International. 2016, 01, 7086390.
38. Wenping Zhang, Jian Wang, Chen Zhang, Qiang Fang, Jianhong Shu, Si Li, Jia Jin, Dan Wang, Zuoming Nie, Zhengbing Lv, Yaozhou Zhang*. Synergetic Protein Factors That Improve rhGM-CSF Absorption via an Oral Route Exist in Silkworm Pupae, Molecular Pharmaceutics, 2015, 12(5): 1347-1355.
39. Jia Jin, Yifan Shan, Fan Yang, Hua Lai, Hongwei Tan, Xiaofeng Liu, Jie Tang*, Qiang Fang*. Organic photosensitizers with N-carboxymethyl pyridinium acceptor/anchoring group for dye-sensitized solar cells, Synthetic Met. 2012, 162, 2222-2227.
40. Chuanwen Sun*, Jun Zhu, Haifeng Wang, Jia Jin, Jiahua Xing, Dingrong Yang. Chiral 1, 5-disubstituted 1, 3, 5-hexahydrotriazine-2-N-nitroimine analogues as novel potent neonicotinoids: Synthesis, insecticidal evaluation and molecular docking studies, European Journal of Medicinal Chemistry. 2011, 46, 11-20.
41. Chuanwen Sun*, Jia Jin, Jun Zhu, Haifeng Wang, Dingrong Yang, Jiahua Xing. Discovery of bis-aromatic ring neonicotinoid analogues fixed as cis-configuration: Synthesis, insecticidal activities, and molecular docking studies, Bioorg. Med. Chem. Lett. 2010, 20, 3301–3305.
42. Chuan-wen Sun*, Jun Zhu, Jia Jin and Yang Ding-rong. Acta Cryst Section E. 2010, 66, o1457-o1458.
43. Chuanwen Sun*, Dingrong Yang, Haifeng Wang, Jia Jin, Jun Zhu. Nitromethylene Neonicotinoids Analogues with Tetrahydropyrimidine Fixed cis-Configuration: Synthesis, Insecticidal Activities, and Molecular Docking Studies, J. Agric. Food. Chem. 2010, 58, 3415–3421. (Top Journal)
44. Zhu Jun, Sijia Xue*, Haifeng Wang, Yang Ding-Rong, Jin Jia. Syntheses and Crystal Structures of 1, 5-Disubstituted 1, 3, 5-Hexahydro-triazine-2-(N-nitro) imines, Chinese J. Struct. Chem. 2010, 3, 400-406.
专利
1. 金甲,叶飞,王磊,胡浩峰,骆富林,陈欣,袁梦婷,白崇斌，新型复合自组装多肽水凝胶及其制备和应用，专利申请号：202310679388.1 （实质审查中）
2. 马祯一,金甲,钱萍,张晓芳,胡衍泽,张佳丽,张淑窈,袁梦婷，一种一步法苏木素伊红染色混合试剂，专利申请号：202311803497.6 （实质审查中）
3. 金甲，杨帆，叶飞，王磊，刘陈育，张晓健，刘志豪，张伦，一种具有I型PRMT抑制活性的化合物及其应用，专利申请号：202210733537.3（已授权）
4. 叶飞，金甲，王磊，PRMT I型甲基转移酶抑制活性化合物及其制备与应用，专利申请号：202110811481.4（已授权）
5. 叶飞，金甲，王磊，徐明，张文平，舒建洪，吕正兵，一种抗菌止血膜及其制备方法和应用，专利申请号：202110059037.1
6. 金甲，叶飞，吕正兵，张楠，姚颖洁，代凯丽，季志孝，徐明，一种含小檗碱的抗菌止血微球的制备方法及其应用，专利申请号：201811225912.3（已授权）
7. 叶飞，金甲，代凯丽，王林，张伦，一种含抗菌成分小檗碱的止血微球及其制备方法和应用，专利申请号：201811483221.3（已授权）
8. 刘陈育，叶飞，金甲，张楠，姚颖洁，代凯丽，季志孝，徐明，吕正兵，可吸收仿血小板生物质材料及其应用，专利申请号：201810247846.3（已授权）
9. 罗成，金甲，谢轶谦，姚志艺，叶飞，王晨，蒋昊，张元元，陆文超，蒋华良，PRMT I型抑制剂及其制备方法和用途，专利申请号：201710348647.7（已授权）
10. 金甲，杨玉民，叶飞，一种可吸收抗菌止血微球、制备方法及其应用，专利申请号：201610526892.8
11. 舒建洪，吕正兵，金甲，张超，朱浩艳，叶速东，一种抗菌促生长动物专用药3-甲基-2-乙醇基喹噁，专利申请号：201611203253.4（已授权）
12. 金甲，于晗，叶飞，吕正兵，一种含二氢吡啶硫酮类化合物或其药学上可接受的盐、制备及其应用，专利申请号：201610516463.2（已授权）
13. 舒建洪，吕正兵，金甲，张超，朱浩艳，叶速东，一种饲料添加剂脱镁叶绿素的提取方法，专利申请号：201611229326.7（已授权）
14. 金甲，吕正兵，叶飞，张文平，舒建洪，一种苯并三氮唑类衍生物及其制备方法，专利申请号：201410466706.7（已授权）
15. 汤杰、李佳、金甲、蒋昊文、李静雅、杨帆、杨玲玲、何海兵、盛丽、于丽芳、张杰锋、阮礼波、石敏、李念，N-(1,3-二氧代异吲哚啉)芳酰胺类化合物及其制备方法和应用，专利申请号：201410410345.4（已授权）
16. 薛思佳，杨定荣，金甲，陈志明，方治坤，含L-α-氨基酸脂的Z式构型新烟碱类杀虫剂及制备，专利申请号：200910057324.8（已授权）
