苗蒙

性 别：女

出生年月：1988年11月

所 在 学 科 组：生物制药

办 公 室：6#529

电子邮件：miaomeng@zstu.edu.cn

苗蒙，女，博士，硕士生导师。毕业于武汉大学生命科学学院，专业方向病毒学。主要从事家蚕功能基因和杆状病毒分子生物学及表观遗传学在病毒与宿主相互作用中的机制研究。主持国家自然科学基金青年项目1项，横向项目1项，作为主要完成人参与多项国家自然科学基金面上项目及国际（地区）合作与交流项目。在Immunity、Science Advances、International Journal of Biological Macromolecules、Virologica Sinica等期刊上发表论文23篇。

科研项目：

1、国家自然科学基金青年科学基金项目，32302818，家蚕组蛋白乙酰转移酶BmMOF与BmNPV晚期表达因子LEF-6互作抑制病毒侵染的分子机制研究，2024-01-01至2026-12-31，在研，主持。

2、浙江理工大学基本科研业务费青年创新专项，24042130-Y，家蚕组蛋白乙酰转移酶BmMOF与促凋亡蛋白Bmp53互作抑制核型多角体病毒BmNPV侵染的分子机制，2024-01-01至2025-12-31，在研，主持。

3、浙江理工大学技术开发项目，22040512-J，碳酸盐矿化菌的分离筛选及生物碳酸盐水泥的研制，2022-09-30至2025-9-30，在研，主持。

4、国家自然科学基金委员会，面上项目，31870827，肠道病毒71型介导的宿主组蛋白H3切割及其在感染中的作用研究, 2019-01-01 至 2022-12-31, 59万元, 结题, 参与。

5、国家自然科学基金委员会，面上项目，31670161，磷酸化修饰对肠道病毒71型非结构蛋白2C的调控机制研究，2017-01-01至2020-12-31, 60万元, 结题, 参与。

6、国家自然科学基金委，国际(地区)合作与交流项目，31761130075，小RNA病毒2C蛋白与诺如病毒2C类似蛋白的功能与结构研究，2017-03至2020-2，41万元, 结题, 参与。

科研成果：

Miao M*, Bai SM, Huang YY, Zhang JW, Xu KL, Chen Y, Qian QT, Dong J, Nie HM, Mei J, Tong FD, Yu W*. Histone acetyltransferase BmMOF inhibits the proliferation of the Bombyx mori nucleopolyhedrovirus by targeting Bmp53. Int J Biol Macromol. 2025, 305(Pt 2):141186.

Mei J, Xu K, Huang Y, Zhang J, Qian Q, Dong J, Tong F, Yu W, Miao M*. Cloning and characterization of the histone variant gene H2A.Z in Bombyx mori. Arch Insect Biochem Physiol. 2024, 116(3): e22136.

Bai S, Niu Q, Wu Y, Xu K, Miao M*, Mei J*. Genome-Wide Identification of the NAC Transcription Factors in Gossypium hirsutum and Analysis of Their Responses to Verticillium wilt. Plants (Basel). 2022, 11(19):2661.

慕蓉蓉,牛晴晴,孙玉强,梅俊,苗蒙.陆地棉MYB类转录因子基因GhTT2克隆及功能初步分析[J].遗传,2022,44(08):720-728.

Meng Miao; Gang Deng; Xiaobei Xiong; Yang Qiu; Wenda Huang; Meng Yuan; Fei Yu; Shimei Bai; Xi Zhou; Xiaolu Zhao ; Enterovirus 71 3C proteolytically processes the histone H3 N-terminal tail during infection, Virologica Sinica, 2022, 37, 314-317.

Meng Miao; Fei Yu; Danya Wang; Yongjia Tong; Liuting Yang; Jiuyue Xu; Yang Qiu; Xi Zhou; Xiaolu Zhao ; Proteomics Profiling of Host Cell Response via Protein Expression and Phosphorylati on upon Dengue Virus Infection, Virologica Sinica, 2019, 34: 549-562.

Mei J, Mu R, Niu, Q, Zhu H, Chen R, Cai X, Miao M, Yu D, Ke L, Sun Y. A MYB transcription factor GhTT2 of Gossypium hirsutum regulates proanthocyanidin accumulation and improves osmotic tolerance in Arabidopsis. Plant Cell Tiss Organ Cult. 2024,157, 39.

Zhang X, Ma S, Gu C, Hu M, Miao M, Quan Y, Yu W. K64 acetylation of heat shock protein 90 suppresses nucleopolyhedrovirus replication in Bombyx mori. Arch Insect Biochem Physiol. 2024, 115(1):e22079.

Mei J, Niu Q, Xu K, Huang Y, Bai S, Zhu J, Li H, Miao M, Tong F, Yu D, Ke L, Sun Y. GhmiR858 Inhibits the Accumulation of Proanthocyanidins by Targeting GhTT2L in Cotton (Gossypium hirsutum). J Agric Food Chem. 2023, 71(41):15341-15351.

Wu J, Shen S, Gao X, Miao M, Quan Y, Yu W. Effects of LEF-11 acetylation modification on the regulation of baculovirus infection. Acta Virol. 2023, 67(1):42-50.

Hu M, You Y, Li Y, Ma S, Li J, Miao M, Quan Y, Yu W. Deacetylation of ACO2 Is Essential for Inhibiting Bombyx mori Nucleopolyhedrovirus Propagation. Viruses. 2023, 15(10):2084.

Hu M, Zhu Y, Mo Y, Gao X, Miao M, Yu W. Acetylation of citrate synthase inhibits Bombyx mori nucleopolyhedrovirus propagation by affecting energy metabolism. Microb Pathog. 2022,173(Pt B):105890.

Mei J, Wu Y, Niu Q, Miao M, Zhang D, Zhao Y, Cai F, Yu D, Ke L, Feng H, Sun Y. Integrative Analysis of Expression Profiles of mRNA and MicroRNA Provides Insights of Cotton Response to Verticillium dahliae. Int J Mol Sci. 2022, 23(9):4702.

Gao X, Xu S, Mo Y, Zhu Y, Chen X, Miao M, Quan Y, Yu W. Acetylation of fructose-bisphosphate aldolase-mediated glycolysis is essential for Bombyx mori nucleopolyhedrovirus infection. Microb Pathog. 2022, 170:105695.

Mao F, Zhu Y, Gao X, Chen X, Ngowo J, Miao M, Quan Y, Yu W. HSP/HSC70 activity is required for Bombyx mori nucleopolyhedrovirus replication at the early infectious phase. Microb Pathog. 2021, 153:104647.

Mao F, Chen X, Ngowo J, Zhu Y, Lei J, Gao X, Miao M, Quan Y, Yu W. Deacetylation of HSC70-4 Promotes Bombyx mori Nucleopolyhedrovirus Proliferation via Proteasome-Mediated Nuclear Import. Front Physiol. 2021, 12:609674.

Gao X, Lei J, Zhu Y, Chen X, Mao F, Miao M, Quan Y, Yu W. Role of the Bombyx mori nucleopolyhedrovirus LEF3 acetylation on viral replication. Microb Pathog. 2021, 158:105109.

Qiu Y, Xu YP, Wang M, Miao M, Zhou H, Xu J, Kong J, Zheng D, Li RT, Zhang RR, Guo Y, Li XF, Cui J, Qin CF, Zhou X. Flavivirus induces and antagonizes antiviral RNA interference in both mammals and mosquitoes. Sci Adv. 2020, 6(6): eaax7989.

朱亚杰; 苗蒙; 闫慧慧; 全滟平; 于威; 家蚕Ada3蛋白对杆状病毒复制及宿主细胞凋亡的影响, 蚕业科学, 2020, 46(2): 171-177.

Qiu Y, Xu Y, Zhang Y, Zhou H, Deng YQ, Li XF, Miao M, Zhang Q, Zhong B, Hu Y, Zhang FC, Wu L, Qin CF, Zhou X. Human Virus-Derived Small RNAs Can Confer Antiviral Immunity in Mammals. Immunity. 2017,46(6):992-1004.e5.

Qiu Y, Miao M, Wang Z, Liu Y, Yang J, Xia H, Li XF, Qin CF, Hu Y, Zhou X. The RNA binding of protein A from Wuhan nodavirus is mediated by mitochondrial membrane lipids. Virology. 2014, 462-463:1-13.

Qiu Y, Wang Z, Liu Y, Han Y, Miao M, Qi N, Yang J, Xia H, Li X, Qin CF, Hu Y, Zhou X. The self-interaction of a nodavirus replicase is enhanced by mitochondrial membrane lipids. PLoS One. 2014, 9(2):e89628.

Qiu Y, Wang Z, Liu Y, Qi N, Miao M, Si J, Xiang X, Cai D, Hu Y, Zhou X. Membrane association of Wuhan nodavirus protein A is required for its ability to accumulate genomic RNA1 template. Virology. 2013, 439(2):140-51.